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徐晓玲


【发布时间:2024-05-14 10:48:30  点击量:


徐晓玲,1988年10月,博士,副教授。长期从事纳米材料抗肿瘤免疫方面的教学和研究工作。正在主持国家自然科学基金面上项目、浙江省高校领军人才项目;已承担完成国家自然科学基金青年项目、浙江省自然科学基金探索项目、中国博士后科学基金面上资助和浙江省博士后科学基金科研项目择优资助;参与国家自然科学基金重点研发项目、浙江省自然科学基金重大项目、浙江省科技厅重大项目等多项国家和省部级重大课题的研究工作。以第一/共通身份在Nature Communications、Advanced Materials、Nano Today、ACS Nano等国际刊物上发表SCI收录论文40余篇,总影响因子大于300。

教学工作:

主要讲授的本科生课程有:《药理学》、《临床安全用药》等。

近五年主持和参与的科研项目:

(1)铁蛋白归巢纳米给药系统介导的肿瘤自发性铁自噬和免疫的协同治疗作用研究,国家自然科学面上基金(82372109), 2024-01至2027-12,在研

(2)浙江省高校领军人才培养计划, 2022-01至2026-12,在研

(3)仿生纳米笼嵌合温敏凝胶的肝癌介入栓塞、光动力及饥饿多模式协同治疗研究,国家自然科学青年基金(82001932), 2021-01至2023-12,已提交结题

(4)基于多聚唾液酸纳米递药系统的三叉神经痛治疗与髓鞘再生研究,浙江省自然科学基金(LQ21H300008), 2021-01至2023-12,已提交结题

(5)自发光纳米笼嵌合温敏凝胶的肝癌介入栓塞、光动力及饥饿多模式协同治疗研究,中国博士后科学基金(2020M681902), 2021-01至2021-04,结题

(6)形状记忆纳米笼嵌合温敏凝胶的肝癌介入栓塞、化学动力学及饥饿多模式协同治疗研究,浙江省博士后科学基金(ZJ2020034), 2021-01至2021-04,结题

近五年成果及奖励:

代表性论文:

1.Minxia Zhu#, Luwen Zhu#, Yuchan You, Mingchen Sun, Feiyang Jin, Yanling Song, Jucong Zhang,Xiaoling Xu*, Jiansong Ji*, Yongzhong Du*.Positive chemotaxis ofCREKA-modified ceria@polydopamine biomimetic nanoswimmers for enhanced penetration and chemo-photothermal tumor therapy,ACSNano,2023,17, 17285−17298,IF=17.1

2.Di Liu#, Yanling Song#, Hui Chen, Yuchan You, Luwen Zhu, Jucong Zhang, Xinyi Xu, Jiahao Hu, Xiajie Huang, Xiaochuan Wu,Xiaoling Xu*, Saiping Jiang*, Yongzhong Du*.Anti-VEGFR2 F(ab')2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy,Nature Communications, 2023,14, 8268, IF=16.6

3.Yanling Song, Yuchan You, Xinyi Xu, Jingyi Lu, Xiajie Huang, Jucong Zhang, Luwen Zhu,Jiahao Hu, Xiaochuan Wu,Xiaoling Xu*,Weiqiang Tan,* and Yongzhong Du*.Adipose-Derived Mesenchymal Stem Cell-DerivedExosomes Biopotentiated Extracellular Matrix HydrogelsAccelerate Diabetic Wound Healing and Skin Regeneration,AdvancedScience,2023,10(30):e2304023.IF=15.1

4.XuefangLou#,Jingyi Lu#,Chen Wang,Yanling Song,Luwen Zhu,Yuchan You,JucongZhang,JiahaoHu,XinyiXu,Xiaoling Xu*,Yongzhong Du*.Self-oriented ferritin nanocages mitigate iron overload-induced oxidative stress for acute kidney injury,Chemical Engineering Journal,2023, 466:143227.IF=15.1

5.Bang-Yao Chen#, Si-Ying Hong#, Han-Min Wang#, Yi Shi, Peng Wang, Xiao-Juan Wang, Qian-Yang Jiang, Ke-Da Yang*, Wei Chen*,Xiaoling Xu*.The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles,Particle and Fibre Toxicology. 2023,20(1):38,IF=10.0

6.Luwen Zhu, Yuchan You, Minxia Zhu, Yanling Song, Jucong Zhang, Jiahao Hu, Xinyi Xu,Xiaoling Xu*,Yongzhong Du*, and Jiansong Ji*.Ferritin-Hijacking Nanoparticles Spatiotemporally Directing Endogenous Ferroptosis for Synergistic Anticancer Therapy,AdvancedMaterials, 2022,202207174,IF=29.4

7.Jun Wang, Jing Qi, Feiyang Jin, Yuchan You, Yan Du, Di Liu,Xiaoling Xu*, Minjiang Chen, Gaofeng Shu, Luwen Zhu, Xiaoying Ying, Jiansong Ji*, Weishuo Li*, Yongzhong Du*.Spatiotemporally light controlled “drug-free” macromolecules via upconversion-nanoparticle for precise tumor therapy,Nano Today, 2022, 42, 101360,IF=17.4

8.Xiaoling Xu#, Yan Xue#, Jia-Ying Ding, Zhi-Heng Zhu, Xi-Chen Wu, Yong-Jia Song, Yue-Long Cao, Long-Guang Tang*, Dao-Fang Ding*, Jian-Guang Xu*.Nanodevices for deep cartilage penetration,Acta Biomaterialia,2022,154:23-48.IF=9.7

9.Xiaoling Xu, Nan-Nan Zhang, Gao-Feng Shu, Di Liu, Jing Qi, Fei-Yang Jin, Jian-Song Ji*, Yong-Zhong Du*.A luminol-based self-illuminating nanocageas a reactive oxygen species amplifier toenhance deep tumor penetration andsynergistic therapy,ACSNano,2021, 15, 12, 19394-19408,IF=17.1

10.Ming-Chen Sun,Xiaoling Xu*,Yan Du, Xue-Fang Lou*, Wei Wang, Yu-Chan You, Di Liu,Fei-Yang Jin, Jing Qi, Min-Xia Zhu, Lu-Wen Zhu, Jun Wang, and Yong-Zhong Du*.Biomimetic melanosomes promote orientation-selective delivery and melanocyte pigmentation in theH2O2‑induced vitiligo mouse model,ACSNano,2021,15,17361-17374,IF=17.1

11.Jing Qi#, Feiyang Jin#, Yuchan You,Yan Du,Di Liu,Xiaoling Xu*, Jun Wang,Luwen Zhu,Minjiang Chen,Gaofeng Shu, Liming Wu*, Jiansong Ji*,Yongzhong Du*.Synergistic effect of tumor chemo-immunotherapyinduced by leukocyte-hitchhiking thermal-sensitivemicelles,Nature Communications, 2021,12,4755,IF=16.6

12.Xiaoling Xu#, Mei-Xuan Chen#, Xue-Fang Lou, Yu-Yin Du, Gao-Feng Shu, Jing Qi, Meng-Lu Zhu, Xiao-Ying Ying, Lian Yu*, Jian-Song Ji*, Yong-Zhong Du*.Sialic acid-modified mesoporous polydopamine induces tumor vessel normalization to enhance photodynamic therapy by inhibiting VE-cadherin internalization,Chemical Engineering Journal, 2021, 414, 128743,IF=15.1

13.Xiaoling Xu, Gao-Feng Shu, Xiao-Juan Wang, Jing Qi, Fei-Yang Jin, Qi-Ying Shen, Xiao-Ying Ying*, Jian-Song Ji*, Yong-Zhong Du*.Sialic acid -modified chitosan oligosaccharide-based biphasic calciumphosphate promote synergetic bone formation in rheumatoid arthritistherapy,Journalof Controlled Release, 2020,323:578-590.IF=10.8

专利:

(1)杜永忠;徐晓玲;应晓英;一种唾液酸修饰复合纳米给药系统及制备与应用, 2019-6-24,中国, ZL201910550667.1

(2)杜永忠;王君;徐晓玲;应晓英;一种Aptamer和上转换纳米粒修饰共聚物及合成与应用, 2020-12-2,中国, CN202011399773.3

联系方式:

E-mail:xuxiaoling10@zju.edu.cn



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